Validation Protocols

Choose A Practical Functional Validation Bundle

Two low-cost protocol versions for validating the Energy Score in practice: a fuller version that includes grip strength, and a lighter version that removes the dynamometer requirement.

Back to Mito Map Measured Function Score Research Papers

Recommendation: Use the grip-strength version when you can standardize a dynamometer. Use the no-grip version when you need a simpler field protocol with almost no equipment.

Version 1

Full Bundle With Grip Strength

Best for clinics, research pilots, and higher-rigor follow-up. Adds a direct strength or reserve signal on top of chair-rise performance and fatigue burden.

Grip strength 5x sit-to-stand Fatigue survey

This is the stronger version if your goal is to correlate modeled energy with an objective upper-extremity strength signal.

Open grip-strength protocol

Version 2

Lean Bundle Without Grip Strength

Best for home tracking, quick clinical pilots, or settings where a dynamometer is not available. Keeps performance and symptom burden, but drops the strength-specific measure.

5x sit-to-stand Fatigue survey

This is the simplest low-cost protocol to deploy broadly, but it is slightly less objective than the full bundle.

Open no-grip protocol

How To Choose

Which Version To Use

Choose the grip-strength version if you want the best balance of rigor, cost, and objectivity.
Choose the no-grip version if you want easier deployment across many users or remote settings.
Use the same version consistently within a study or cohort rather than mixing protocols across visits.
If you start lean, you can still add grip strength later as a higher-rigor upgrade.

Practical default: for a first pilot, start with the grip-strength version if you have access to a dynamometer. If not, the no-grip version is still a reasonable real-world validation protocol.

Calculator

Measured Function Score

A separate calculator now converts either protocol into a single observed-function score that can be compared against the modeled Energy Score. It is designed as an operational tracking tool, not a validated clinical scale.

Open measured-function calculator